Titlebook: Gene Therapy and Gene Delivery Systems; David V. Schaffer,Weichang Zhou Book 2005 Springer-Verlag Berlin Heidelberg 2005 Herman.biotechnol

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Nonviral Delivery of Cancer Genetic Vaccines,n the nonviral delivery of antigen-encoded plasmid DNA for the purpose of treating cancer through the human immune system, as this disease has drawn the most attention in this field to date. Brief overviews of dendritic cell immunobiology and the mechanism of immune activation through genetic vaccin

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Advanced Targeting Strategies for Murine Retroviral and Adeno-associated Viral Vectors,lusively, or stealthing the vector against nonspecific interactions with host cells and proteins. These approaches offer the potential advantages of enhanced therapeutic effects, reduced side effects, lowered dosages, and enhanced therapeutic economics. This review will discuss a variety of targetin

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Lentiviral Vectors,rated transgenes. Safety issues, including insertional mutagenesis and replication-competent retroviruses, are discussed. Innate cellular defenses against retroviruses and their implications for human gene therapy with different lentiviral vectors are also addressed.

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Production and Formulation of Adenovirus Vectors,replacement therapy for protein deficiencies tocancer therapeutics to prophylactic vaccines. Consequently, considerable product, process, analytical, and formulation development has been undertaken to support these programs. For example, “gutless”vectors have been developed in order to improve gene

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,Adeno-associated Virus as a Gene Therapy Vector: Vector Development, Production and Clinical Appliclia B, cystic fibrosis, alpha-1-antitrypsin deficiency, and Canavan disease have begun, and reports from these phase I trials support the safety seen in preclinical trials. Eventually, tissue-specific vectors that can potentially evade the immune system will be required to optimize success in gene t