Titlebook: Gene Therapeutics; Methods and Applicat Jon A. Wolff Book 1994 Birkhäuser Boston 1994 DNA.Promoter.Translation.gene expression.gene therapy

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Development of Herpes Simplex Virus Vectors for Gene Transfer to the Central Nervous Systeml disease in a considerable percentage of affected patients. For example, the administration of L-DOPA to Parkinson’s patients may even accelerate the decline in dopamine producing neurons. Other difficulties with traditional therapies are that the blood-brain barrier limits the delivery of systemic

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Book 1994tter op­ portunity. The fITSt reproducible in vivo gene therapy in a whole animal came in 1981. This was in Drosophila, with a transposable element as carrier. Flies were "cured" of a mutant eye color by incorporation of the normal allele, and the effect was transmissible, foreshadowing not only som

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ease by altering or replacing defective genes. H. J. Muller wrote of the great advantages of mutations, "nanoneedles" in his apt term, for delicately probing physiological and chemical processes. In the same spirit, genes could be used to provide treatments of needle point delicacy. Yet, during this

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Y. K. Tong,R.W.K. Chiu,Y.M.D. Lo cardiology, and anesthesiology (Report of the Council on Scientific Affairs, 1989). Due to recent advances in the techniques required for somatic gene transfer and in the ability to produce desired models for human heritable diseases, the stage is now set to extend the range of these areas of biomedical impact to include somatic gene therapy.

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Naturally Occurring , and Poly, Carotenoids approach to somatic gene therapy is entirely based on introducing genes either to correct a prior genetic defect or to augment the genetic repertoire of the recipient cell. The technology of gene transfer is truly one of the cornerstones in molecular genetics.