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Titlebook: Gene Mapping in Laboratory Mammals; Part A Roy Robinson Book 1971 Plenum Publishing Company Ltd. 1971 Laboratory.genes.heredity.mammals

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书目名称Gene Mapping in Laboratory Mammals
副标题Part A
编辑Roy Robinson
视频video
图书封面Titlebook: Gene Mapping in Laboratory Mammals; Part A Roy Robinson Book 1971 Plenum Publishing Company Ltd. 1971 Laboratory.genes.heredity.mammals
描述The present work is an attempt to provide a systematic treatment of genetic linkage in diploid heredity. Part A presents a general account of statistical methods which can be brought to bear on the problem. The primary emphasis is on the practical aspects of estimation. A large proportion, if not the majority, of mutant genes fail to match up to ‘textbook‘ genes-with faultless segregation ratios and expression-yet, these are the materials with which the practical researcher has to cope. For this reason, it is important to know how to deal with the assortment of genes which may display significant deviations from expectation. Part B examines the accumulated data on linkage for most of the laboratory mammals and provides a comprehensive and up-to-date survey. The need for a critical review has often been expressed and it is hoped that the present analysis will fill the gap. The volume of material is probably the most important in the animal kingdom other than that for Drosophila species.
出版日期Book 1971
关键词Laboratory; genes; heredity; mammals
版次1
doihttps://doi.org/10.1007/978-1-4684-2982-4
isbn_softcover978-1-4684-2984-8
isbn_ebook978-1-4684-2982-4
copyrightPlenum Publishing Company Ltd. 1971
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Inviability, Impenetrance and Linkage Detectioninly not distinct, except in a formal sense, for the second arises naturally from a positive answer to the first. It is self-evident that at least two mutant non-allelic genes are necessary for linkage analysis and the first question which must be answered is whether or not the genes conform to the
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Estimation with Normal Gene Ratios should assort at random in the testcross and in the intercross. However, in some crosses, completely random assortment is not realized. In each of the crosses, the four phenotypes can be represented as formed from the original and parental combinations or as recombinations. Formally, linkage is ind
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Estimation with Inviability and Impenetrancee same problems as for impenetrance alone. The expectations may seem more complicated but the estimating formulae are either identical or analogous to many of those given earlier. Locus . will be assumed to be impenetrant and locus . the inviable. The expectations for the coupling testcross with two
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Multipoint Crossesation of multi-point crosses requires an intensive level of analysis which has had few aspirants. In the second place, only fairly recently have extensive linked groups of genes become available which would make such analyses profitable. The way is now open for a more systematic study of multiple li
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Mapping Functionst of the cumulative sum of crossover values for adjacent genes. This is the map expressed in crossover units. When the loci are sited close together, the cumulative sum gives an accurate representation of the chromosome in centimorgans. Unfortunately, when the loci are not sited close together, the
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