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Titlebook: Gene Expression and Its Discontents; The Social Productio Rodrick Wallace,Deborah Wallace Book 20101st edition Springer Science+Business Me

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发表于 2025-3-21 19:29:11 | 显示全部楼层 |阅读模式
书目名称Gene Expression and Its Discontents
副标题The Social Productio
编辑Rodrick Wallace,Deborah Wallace
视频video
概述Includes supplementary material:
图书封面Titlebook: Gene Expression and Its Discontents; The Social Productio Rodrick Wallace,Deborah Wallace Book 20101st edition Springer Science+Business Me
描述.Gene Expression and its Discontents. examines a class of probability models describing how epigenetic context affects gene expression and organismal development, using the asymptotic limit theorems of information theory in a highly formal manner. Taking classic results on spontaneous symmetry breaking abducted from statistical physics in groupoid, rather than group, circumstances, the work suggests that epigenetic information sources act as analogs to a tunable catalyst, directing development into different characteristic pathways according to the structure of external signals. The results have significant implications for epigenetic epidemiology, in particular for understanding how environmental stressors, in a large sense, can induce a broad spectrum of developmental disorders in humans. The authors then apply the perspective to a number of chronic diseases broadly associated with obesity, using data at different scales of observation..
出版日期Book 20101st edition
关键词AIDS; Cancer; Epidemiology; Obesity; gene expression; genes; genetic epidemiology
版次1
doihttps://doi.org/10.1007/978-1-4419-1482-8
isbn_softcover978-1-4899-8531-6
isbn_ebook978-1-4419-1482-8
copyrightSpringer Science+Business Media, LLC 2010
The information of publication is updating

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Groupoid symmetries,points ..; .. and defining equivalence of two states by the existence of a high probability meaningful path connecting them with the same origin and end. Disjoint partition by equivalence class, analogous to orbit equivalence classes for dynamical systems, defines the vertices of the proposed networ
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Developmental disorders,here defined as a complicated set of information sources having source joint uncertainty .(.., …,..) that guides the system into a particular equivalence class of desired developmental behaviors and trajectories. To model the effect of . on development one can, most simply, invoke results from netwo
发表于 2025-3-22 15:08:12 | 显示全部楼层
An interim perspective,odel analogs to data’, possibly at a second order epigenetic hierarchical level. In the real world such calculations would be quite diffcult, particularly given the introduction of punctuated transitions that must be fitted using elaborate renormalization calculations, typically requiring such exoti
发表于 2025-3-22 17:20:08 | 显示全部楼层
The obesity pandemic in the US,c worldwide (e.g., Egger and Swinburn, 1997; Kimm and Obarzanek, 2002; Roth et al., 2004). Current rates of overweight in the US are 61% and 14% in adults and children respectively. Obesity in adults has nearly doubled since 1980, from 15% in 1980 to 27% by 1999 (Welman and Friedberg, 2002). Childho
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Coronary heart disease in the US,nstream authorities characteristically and predictably focused on individual-oriented ‘prevention’ by altered life-style or related medical magic bullet interventions. See Link and Phelan (2000) for a comprehensive critique and review. Indeed, for certain US subpopulations, changes in diet, exercise
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Autoimmune disorders,women, although we will later make some remarks regarding asthma and its relation to life stress and synergism with air pollution. In SLE, arthritis, skin rash, osteoporosis, cataracts, accelerated atherosclerotic vascular disease (ASVD), central nervous system dysfunction, and renal disease, are th
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