| 书目名称 | Gene Engineering in Endocrinology | | 编辑 | Margaret A. Shupnik | | 视频video | | | 概述 | Includes supplementary material: | | 丛书名称 | Contemporary Endocrinology | | 图书封面 |  | | 描述 | During the past five to ten years, a variety of tools has been developed in the disciplines of both gene engineering, and molecular and structural biology. Some of these advances have permitted scientists not only to identify and characterize genes, but also to target these genes by disruption, thus eliminating their function in living animals, and to det- mine the biological responses to altered gene products. This has particular significance in endocrine systems, in which feedback mechanisms between the hypothalamus, pi- itary, and end organs are critical in normal physiology. Interpretation of the physiological significance, or the site of action of specific molecules in this context, has been difficult prior to transgenic technology. Major advances have occurred specifically in the areas of growth and development, and of reproduction. Coupled with analysis of naturally occurring mutations in humans, the use of transgenic animals and in vitro systems has recently allowed endocrinologists to understand the importance of specific thyroid hormone receptor isoforms in vivo, the molecular basis for generalized resistance to thyroid hormones via mutations in the nuclear receptor, and | | 出版日期 | Book 2000 | | 关键词 | Gonadotropin; glucocorticoid; hormone receptors; insulin; nuclear receptors; signaling pathways; thyroid h | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-59259-221-0 | | isbn_softcover | 978-1-61737-147-9 | | isbn_ebook | 978-1-59259-221-0Series ISSN 2523-3785 Series E-ISSN 2523-3793 | | issn_series | 2523-3785 | | copyright | Springer Science+Business Media New York 2000 |
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发表于 2025-3-21 19:24:38
