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Titlebook: Gene Delivery and Therapy for Neurological Disorders; Xuenong Bo,Joost Verhaagen Book 2015 Springer Science+Business Media New York 2015 A

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发表于 2025-3-21 17:49:21 | 显示全部楼层 |阅读模式
书目名称Gene Delivery and Therapy for Neurological Disorders
编辑Xuenong Bo,Joost Verhaagen
视频video
概述Includes cutting-edge techniques to explore gene therapy for neurological disorders.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from th
丛书名称Neuromethods
图书封面Titlebook: Gene Delivery and Therapy for Neurological Disorders;  Xuenong Bo,Joost Verhaagen Book 2015 Springer Science+Business Media New York 2015 A
描述.This volume aims to explore the latest developments in adeno-associated viral and lentiviral vectors as well as the gene therapy strategies for the most common neurological disorders, followed by chapters that include step-by-step guides to viral vector-based gene delivery in animal models used in the authors’ laboratories. Although safe gene manipulation in neural cells can be achieved, it may still be years away from efficacious gene-based treatment of neurological disorders such as Parkinson‘s and Alzheimer’s diseases due to the complexity of the underlying genetic/molecular mechanisms and the difficulty of developing reliable animal models. .Gene Delivery and Therapy for Neurological Disorders. seeks to aid researchers in this vital work.  Written in the popular .Neuromethods. series format, chapters include the kind of detailed description and expert implementation advice that leads to success in the lab..Meticulous and authoritative, .Gene Delivery and Therapy for Neurological Disorders. serves as an ideal guide for researchers attempting to explore the potentials of gene therapy for neurological disorders..
出版日期Book 2015
关键词Adeno-associated viral vectors; Animal models; Gene expression manipulation; Gene therapy; Gene-based tr
版次1
doihttps://doi.org/10.1007/978-1-4939-2306-9
isbn_softcover978-1-4939-5316-5
isbn_ebook978-1-4939-2306-9Series ISSN 0893-2336 Series E-ISSN 1940-6045
issn_series 0893-2336
copyrightSpringer Science+Business Media New York 2015
The information of publication is updating

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,Gene Therapy for Parkinson’s Disease: AAV5-Mediated Delivery of Glial Cell Line-Derived Neurotrophin identified as possible therapeutic molecule for the treatment of neurodegenerative diseases in several different animal models. Delivery of the GDNF has been proven to be very efficient using recombinant AAV vectors. AAV2 has been widely used for the delivery of transgenes to the brain and has eve
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,Gene Delivery and Gene Therapy for Alzheimer’s Disease,efficiently confer long-term expression in a variety of cell types, but innovations including hybrid serotypes, rationally designed capsids, split vectors, specific promoter/enhancer additions, and convection-enhanced delivery have greatly progressed the field of AAV research for neurodegenerative d
发表于 2025-3-22 11:48:59 | 显示全部楼层
,Gene Therapy for Huntington’s Disease,psychiatric manifestations. The underlying genetic cause of HD is a mutation in the huntingtin gene resulting in an expanded polyglutamine tract in huntingtin protein that confers a toxic gain of function. Abnormal intranuclear protein inclusions and the progressive degeneration of medium spiny neur
发表于 2025-3-22 14:05:17 | 显示全部楼层
Gene Therapy Approaches to Promoting Axonal Regeneration After Spinal Cord Injury,nal cord injury and neural repair indicate that the two main obstacles that prevent successful axonal regeneration and functional recovery are the weak intrinsic regenerative capacity of the neurons and the presence of several types of inhibitory molecules in the central nervous system (CNS). Variou
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发表于 2025-3-22 22:39:57 | 显示全部楼层
Targeted Gene Therapy for Ischemic Stroke,re are certain barriers in translating gene-based therapy to the clinical setting. For example, systemic delivery of genes into the brain is prevented by the blood–brain barrier (BBB); intraventricular delivery results in nonspecific distribution and gene expression; and stereotactic injection of ve
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