| 书目名称 | Gamma-Glutamyl Transpeptidases |
| 副标题 | Structure and Functi |
| 编辑 | Immacolata Castellano,Antonello Merlino |
| 视频video | http://file.papertrans.cn/381/380608/380608.mp4 |
| 概述 | Comprehensive, up-to-date overview.Includes supplementary material: |
| 丛书名称 | SpringerBriefs in Biochemistry and Molecular Biology |
| 图书封面 |  |
| 描述 | Gamma-Glutamyl Transpeptidases (γ-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the γ-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released γ-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). γ-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.γ-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson’s disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of γ-GTs and gives information about applications of γ-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine. |
| 出版日期 | Book 2013 |
| 关键词 | Cellular redox homeostasis; Enzymes; Glutathione metabolism; Inflammation; Oxidative stress; Transferases |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-0348-0682-4 |
| isbn_softcover | 978-3-0348-0681-7 |
| isbn_ebook | 978-3-0348-0682-4Series ISSN 2211-9353 Series E-ISSN 2211-9361 |
| issn_series | 2211-9353 |
| copyright | The Author(s) 2013 |
|Archiver|手机版|小黑屋|
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