| 书目名称 | Galanin | | 编辑 | Tomas Hökfelt | | 视频video | | | 概述 | Comprehensive collection of information on galaninergic functions and mechanisms.Explains how a new methodological approach can lead to the detection of a new substance class.Describes potential appli | | 丛书名称 | Experientia Supplementum | | 图书封面 |  | | 描述 | Galanin is a neuropeptide found both in the central and peripheral nervous system. The 29-amino acid peptide (named after its N-terminal glycine and C-terminal alanine) was identified in 1983 by its C-terminal amidation. This ‘reverse‘ approach, that is to discover a substance through a distinct chemical feature, and only subsequently to characterize its biological activity, was novel and has been successful in the identification of several other peptides.After the structure of galanin was determined in 1983, functional studies wereperformed with material purified from natural sources until the synthetic form of the peptide became available. Galanin can act as transmitter, modulator and trophic factor, and is involved in a number of physiologicalprocesses such as hormone secretion, cardiovascular mechanisms, feeding and cognition. This peptide may also be of significance for a number of pathological processes/disorders including pain, depression, Alzheimer‘s disease, epilepsy, addiction and cancer. This wide diversity of actions is mediated by three galanin receptor subtypes. The studies reviewed in this volume give a fairly complete overview of the spectrum of the biological actio | | 出版日期 | Book 2010 | | 关键词 | Alzheimer‘s disease; CNS; alcohol; behavior; biological; energy; homeostasis; molecule; nervous system; pain; | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-0346-0228-0 | | isbn_softcover | 978-3-0348-0312-0 | | isbn_ebook | 978-3-0346-0228-0Series ISSN 1664-431X Series E-ISSN 2504-3692 | | issn_series | 1664-431X | | copyright | Springer Basel AG 2010 |
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发表于 2025-3-21 16:52:26
