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Titlebook: GPCRs: From Deorphanization to Lead Structure Identification; H. Bourne,R. Horuk,H. Michel Conference proceedings 2007 Springer-Verlag Ber

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发表于 2025-3-21 18:28:22 | 显示全部楼层 |阅读模式
书目名称GPCRs: From Deorphanization to Lead Structure Identification
编辑H. Bourne,R. Horuk,H. Michel
视频video
丛书名称Ernst Schering Foundation Symposium Proceedings
图书封面Titlebook: GPCRs: From Deorphanization to Lead Structure Identification;  H. Bourne,R. Horuk,H. Michel Conference proceedings 2007 Springer-Verlag Ber
描述.Based on the international workshop .GPCRs: From Deorphanisation to Lead Structure. .Identification., held in Berlin in May 2006, the book highlights the following topics: Structure of GPCRs, Design of GPCR Ligands, GPCR Signalling, Deorphanization and Assay Development. All chapters are written by leading experts in the field, discussing the most recent state of the art. They give insight into the approaches taken by industry and academia to address GPCRs and depict how mature this target class-oriented research has become in the last decade. The book reflects the actual trends in the fast-emerging field of GPCR research in academia and industry..
出版日期Conference proceedings 2007
关键词GPCRs; Orphan GPCRs; PCR; in silico; screening; structure, function, signalling
版次1
doihttps://doi.org/10.1007/978-3-540-48982-5
isbn_softcover978-3-642-08031-9
isbn_ebook978-3-540-48982-5Series ISSN 0947-6075
issn_series 0947-6075
copyrightSpringer-Verlag Berlin Heidelberg 2007
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QSAR Modeling of GPCR Ligands: Methodologies and Examples of Applications,oaches to GPCR ligands. We conclude with the comments on exciting developments in the QSAR modeling of GPCR ligands that focus on the study of emerging data sets of compounds with dual or even multiple activities against two or more of GPCRs.
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High-Throughput Lead Finding and Optimisation for GPCR Targets,wledges the importance of parameters beyond potency and embraces the gain in knowledge of the last decade. This manuscripts attempts to summarise some of the changes and progress made across the pharmaceutical industry to design an efficient and effective strategy for finding and optimising small molecules modulating the activity of GPCRs.
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Conference proceedings 2007dress GPCRs and depict how mature this target class-oriented research has become in the last decade. The book reflects the actual trends in the fast-emerging field of GPCR research in academia and industry..
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A Short History of Modern Moneywards the discovery of small molecule antagonist, that so far have been mainly focused on the HCMV-encoded GPCR US28. This virus-encoded receptor might be involved in cardiovascular diseases and cancer and seems an interesting target for drug intervention.
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