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Titlebook: GM3 Signaling; Cheorl-Ho Kim Book 2020 Springer Nature Singapore Pte Ltd. 2020 Gangliosde.GM3.Sialic acid.sugar code.Anti-Tumor.EGFR-GM3 i

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Basic Function of GM3 as an Interacting Molecule,nflammatory signaling. In fact, the inflammatory responses in intestinal mucosa reduce the amount of GM3 and GD3 in the mucosa region. GM3 production level is involved in expression level of proinflammatory mediators such as cytokines, chemokine networks, and arachidonic acid metabolites. Dietary su
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GD3 Mimetics with a Neurite Forming Capacity,ated with the CJP, indicating the potential neuritogenic capacity like NGF capacity [2]. Also, LLG ganglioside prepared from the water and lipid extracts of . and . as other species of starfishes showed the similar neuritogenesis potentials [3, 4]. The neuritogenic effects of the starfish preparatio
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GM3 as a Pathogenic Infection Receptor,ase, and the result indicates the involvement of SA-linked receptors present in the cell surfaces of host [2]. Host infection with rotavirus strain SA11 was also blocked by treatments with sialylated glycoproteins [3] and by the GM1 ganglioside [4]. Rotavirus strain SA11 binds to the nonacid GSL gan
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Membrane Ganglioside-Specific Neuraminidase 3 (NEU3) Regulates GM3 Signaling,ases are characteristic for the different properties, which each type has a unique function due to their subcellular location and substrate specificities for enzymatic catalysis. A decade ago, only three mammalian enzyme types of the lysosomal neuraminidase (known as NEU1), cytosolic form (known as
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Regulation of GM3-Mediated EGFR Signaling by NEU3 Sialidase,in and its EGFR dimerization [10]. Because the importance of sialylation in glycolipid and glycoprotein become uncovered during the last two decades, the relation between the sialylated glycolipids and its degrading sialidase has been the hot topic in the progression of cancer and tumorigenic transf
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