Titlebook: G Proteins, Receptors, and Disease; Allen M. Spiegel (Chief, Metabolic Diseases Branch Book 1998 Springer Science+Business Media New York

小故事

Introduction to G-Protein-Coupled Signal Transduction and Human Disease,er reviews our current understanding of the structure and function of G proteins and the receptors to which they couple, offers some general considerations on how mutations in G proteins and GPCR cause disease, and gives a broad overview of disorders caused by defects in G-protein-coupled signal tra

玩忽职守

braggadocio

crockery

,Gα12- and Gα13-Subunits of Heterotrimeric G-Proteins A Novel Family of Oncogenes,t a common structural motif consisting of the presence of seven transmembrane-spanning domains ., a property that was also predicted for the protein product of the . oncogene on the basis of its nucleotide sequence .. This finding provided the first link between cellular transformation and GPCRs.

侵蚀

Hypo- and Hyperthyroidism Caused by Mutations of the TSH Receptor,vailability of iodine. Regulation of thyroid function is thus mainly of a “tonic” nature, with virtually no physiological circumstances in which the gland should be put completely at rest. This chapter concentrates on the regulatory actions of thyrotropin via its receptor.

adj忧郁的

一回合

带来

Book 1998 basis of diseases ranging from obesity to malignancy. The basic understanding of the complex signal transduction process achieved here provides a firm foundation for future efforts to prevent and cure these diseases.

侵略

Harpoon

Allen M. Spiegel (Chief, Metabolic Diseases Branch