| 书目名称 | G Protein-Coupled Receptors in Drug Discovery | | 编辑 | Wayne R. Leifert | | 视频video | | | 概述 | Contains several comprehensive reviews of GPCR screening technologies by authoritative leaders.Provides an easily accessible reference volume for cell-based GPCR screening written by leading researche | | 丛书名称 | Methods in Molecular Biology | | 图书封面 |  | | 描述 | The G protein-coupled receptors (GPCRs) and associated peripheral G proteins underpin a multitude of physiological processes. The GPCRs represent one of the largest superfamilies in the human genome and are a significant target for bioactive and drug discovery programs. It is estimated that greater than 50% of all drugs, including those in development, currently target GPCRs. Many of the characterized GPCRs have known ligands; however, approximately 20% of GPCRs are described as orphan GPCRs, apparent GPCRs that share the generic high-level structure charact- istic of GPCRs but whose endogenous ligand is not known. Therefore, it is expected that the field of GPCR drug discovery and development will greatly expand in the coming years with emphasis on new generations of drugs against GPCRs with unique therapeuticuseswhichmayincludedrugssuchasallostericregulators,inverseagonists, and identification of orphan GPCR ligands. AswelearnmoreaboutthemolecularsignalingcascadesfollowingGPCRactivation, we acquire a better appreciation of the complexity of cell signaling and as a result, also acquire a vast array ofnew molecularmethods toinvestigate these andother processes. Thegeneralaimofthisb | | 出版日期 | Book 2009 | | 关键词 | Calcium; Cellular signalling; Chemokine; Drug development; GPCRs; Ligands; physiology | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-60327-317-6 | | isbn_softcover | 978-1-4939-5706-4 | | isbn_ebook | 978-1-60327-317-6Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Humana Press 2009 |
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发表于 2025-3-21 19:15:06
