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Titlebook: G Protein-Coupled Receptor Signaling; Methods and Protocol Mario Tiberi Book 2019 Springer Science+Business Media, LLC, part of Springer Na

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书目名称G Protein-Coupled Receptor Signaling
副标题Methods and Protocol
编辑Mario Tiberi
视频video
概述Includes cutting-edge techniques.Provides step-by-step detail essential for reproducible results.Contains key implementation advice from the experts
丛书名称Methods in Molecular Biology
图书封面Titlebook: G Protein-Coupled Receptor Signaling; Methods and Protocol Mario Tiberi Book 2019 Springer Science+Business Media, LLC, part of Springer Na
描述This detailed volume assembles comprehensive protocols to assist with the study of structural, molecular, cell biological, and in vivo facets of GPCRs, and to enable the development of experimental tools for screening novel GPCR drugs. Sections explore the tweaking of ligands, bioluminescence and FRET approaches, specific GPCR signaling properties, as well as visualization of subcellular compartmentalization. Written for the highly successful .Methods in Molecular Biology. series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. .Authoritative and practical, .G Protein-Coupled Receptor Signaling: Methods and Protocols. serves as an ideal reference for life scientists working in a variety of research fields including molecular pharmacology, cell and developmental biology, brain behavior and physiology, drug development and screening..Chapter  4 is available open access under a CC BY 4.0 license via link.springer.com..
出版日期Book 2019
关键词Transmembrane protein families; Molecular pharmacology; Brain physiology; Drug development; Developmenta
版次1
doihttps://doi.org/10.1007/978-1-4939-9121-1
isbn_ebook978-1-4939-9121-1Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightSpringer Science+Business Media, LLC, part of Springer Nature 2019
The information of publication is updating

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1064-3745 ding molecular pharmacology, cell and developmental biology, brain behavior and physiology, drug development and screening..Chapter  4 is available open access under a CC BY 4.0 license via link.springer.com..978-1-4939-9121-1Series ISSN 1064-3745 Series E-ISSN 1940-6029
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Book 2019ecular pharmacology, cell and developmental biology, brain behavior and physiology, drug development and screening..Chapter  4 is available open access under a CC BY 4.0 license via link.springer.com..
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Assessment of Conformational State Transitions of Class B GPCRs Using Molecular Dynamicsapplied to analyze the simulations and identify key features within each conformational ensemble, which help distinguish the ligand-bound states of the PAC. receptor from the ligand-free one. Further, the Markov State Model has emerged as a key approach to construct the transition network and connec
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Optical Regulation of Class C GPCRs by Photoswitchable Orthogonal Remotely Tethered Ligandsles are difficult to disentangle. The desire to manipulate class C GPCRs with spatiotemporal precision, genetic targeting, and subtype specificity has led to the development of a variety of photopharmacological tools. Of particular promise are the photoswitchable orthogonal remotely tethered ligands
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