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Titlebook: G Protein-Coupled Receptor Genetics; Research and Methods Craig W. Stevens Book 2014 Springer Science+Business Media New York 2014 G Protei

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书目名称G Protein-Coupled Receptor Genetics
副标题Research and Methods
编辑Craig W. Stevens
视频video
概述Explores the powerful and versatile g protein-coupled receptors and their application in health and medicine.Features practical methods that are lab-proven and ready to use.Includes expert opinions on
丛书名称Methods in Pharmacology and Toxicology
图书封面Titlebook: G Protein-Coupled Receptor Genetics; Research and Methods Craig W. Stevens Book 2014 Springer Science+Business Media New York 2014 G Protei
描述.G Protein.‐.Coupled Receptor Genetics: Research and Methods in the Post.‐.Genomic Era. features practical techniques inspired by the fast moving GPCR field. From powerful bioinformatic tools tracing the evolution of GPCRs, to methods for the cellular transfection of engineered viruses containing GPCRs, to optogenetic techniques that produce light-activated GPCRs in live mice, what was once science fiction is now science fact. This detailed volume includes sections covering genetic mechanisms, a genetic toolbox for GPCR discovery, as well as genetic aspects of G protein-coupled receptors in health and medicine. Written for the .Methods in Pharmacology and Toxicology. series, this book contains the kind of key implementation advice that encourages successful results in the lab..Authoritative and easy to use, .G Protein.‐.Coupled Receptor Genetics: Research and Methods in the Post.‐.Genomic Era. serves as an ideal guide for researchers aiming to continue our progress in this dynamic and exciting area of study..
出版日期Book 2014
关键词G Protein-Coupled Receptors; GPCRs; Genetic Mechanisms; Membrane Protein; Receptor Discovery; Proteomics
版次1
doihttps://doi.org/10.1007/978-1-62703-779-2
isbn_softcover978-1-4939-6332-4
isbn_ebook978-1-62703-779-2Series ISSN 1557-2153 Series E-ISSN 1940-6053
issn_series 1557-2153
copyrightSpringer Science+Business Media New York 2014
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G Protein-Coupled Receptor Genetics978-1-62703-779-2Series ISSN 1557-2153 Series E-ISSN 1940-6053
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Katheter-assoziierte Infektionenategorize those genes, and follow their evolutionary history. Being present in fungi, plants, and unicellular eukaryotes, GPCR must have evolved before the plant-fungi-animal split about 1.5 billion years ago. Phylogenetic analyses revealed several kinds of evolutionary patterns that occurred during
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https://doi.org/10.1007/978-3-662-05545-8 different vertebrate species. There is evidence for the existence of opioid receptors from very early in evolution, and here we discuss a possible evolutionary path for their development. The physiological characteristics of the endogenous opioid system as well as the biochemical and pharmacologica
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1x1 der chirurgischen Instrumentecting proteins, or modulate downstream signaling molecules. Where appropriate agents are unobtainable, alternative molecular methods have been developed to determine the specific roles that individual proteins play in GPCR regulation and signaling. One such method utilizes RNA interference (RNAi) to
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https://doi.org/10.1007/978-3-642-50767-0trol of neuronal signaling and could allow for the study of receptor pathways that occur faster than the rate of diffusion. Furthermore, with the aid of implantable light devices, light-activated receptors have the potential for use in live animals and later in humans to control and cure G protein-c
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