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Titlebook: G Protein Signaling Mechanisms in the Retina; Kirill A. Martemyanov,Alapakkam P. Sampath Book 2014 Springer Science+Business Media New Yor

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发表于 2025-3-21 17:09:50 | 显示全部楼层 |阅读模式
书目名称G Protein Signaling Mechanisms in the Retina
编辑Kirill A. Martemyanov,Alapakkam P. Sampath
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概述Includes descriptions of all GPCR-mediated signaling pathways in the retina that contribute to visual and circadian function.Brings together the most prominent experts in retinal biology, and it chall
丛书名称Springer Series in Vision Research
图书封面Titlebook: G Protein Signaling Mechanisms in the Retina;  Kirill A. Martemyanov,Alapakkam P. Sampath Book 2014 Springer Science+Business Media New Yor
描述The main purpose of this volume is to provide a focused analysis of the function of the G protein-coupled signaling pathways that operate in the interconnected network of retinal neurons as they detect and encode the information carried by light. The organization of this volume will generally follow the path of signal flow in the retina. First we will describe recent advances in understanding the phototransduction cascade of rod and cone photoreceptors, which use signaling cascade based on the GPCR rhodopsin to transduce incident light into neural activity. Chapters will be devoted to unique specializations of the two major types of photosensitive cells that comprise the predominant input for our spatial and color vision. Subsequently, the mechanisms of synaptic information encoding by retinal ON bipolar cells will be described, where the GPCR mGluR6 plays a fundamental role. Chapters in this section will examine macromolecular organization of the mGluR6 signaling pathway as well as current understanding of its function. The functional characteristics of this signaling mechanism will be explored in detail. Additionally, this section will cover the role of dopamine receptors in modu
出版日期Book 2014
关键词G protein; GPCR; Retina; Signal transduction; vision; Receptors
版次1
doihttps://doi.org/10.1007/978-1-4939-1218-6
isbn_softcover978-1-4939-5506-0
isbn_ebook978-1-4939-1218-6Series ISSN 2625-2635 Series E-ISSN 2625-2643
issn_series 2625-2635
copyrightSpringer Science+Business Media New York 2014
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G Protein Deactivation Mechanisms in Vertebrate Phototransductionion and other senses, modulate neurotransmission, and are required for hormonal actions. The signaling system involves three groups of molecules, namely, the receptors with heptahelical transmembrane motifs, the trimeric G proteins themselves, and the effectors through which G proteins alter cellula
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Interdependence Among Members of the mGluR6 G-protein Mediated Signalplex of Retinal Depolarizing Bior decrements (OFF) in light intensity. The divergence of these two pathways occurs at the first synapse. The OFF pathway is mediated via Off-bipolar cells that hyperpolarize in response to light increments because they utilize ionotropic glutamate receptors. On-bipolar cells that initiate the ON pa
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Modulation of TRPM1 and the mGluR6 Cascade in ON Bipolar Cellso light (and therefore cone transmitter) with opposite polarities, each has evolved very different postsynaptic mechanisms to solve this problem. The OFF bipolar cell expresses ionotropic α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) and kainate glutamate receptors, conferring depolar
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The Role of Dopamine in Fine-Tuning Cone- and Rod-Driven Visionretinal neurons. This expansive expression pattern allows dopamine to regulate visual processing at different cellular sites of the retinal circuitry. One of the most extensively studied functions of dopamine is its role in mediating the shift from rod-dominant to cone-dominant vision at the transit
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The Functional Properties of the G Protein-Coupled Receptor Melanopsin in Intrinsically Photosensitiscovery of an additional photopigment melanopsin (a G protein-coupled receptor, GPCR) expressed in a small subset of intrinsically photosensitive retinal ganglion cells (ipRGCs) has expanded upon the conventional view of light detection and information flow in the retina. In this chapter, we will hi
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