| 书目名称 | Fragment-Based Methods in Drug Discovery |
| 编辑 | Anthony E. Klon |
| 视频video | |
| 概述 | Includes cutting-edge methods and examples of successful fragment-based drug design.Provides step-by-step detail essential for reproducible results.Features implementation tips from the experts.Includ |
| 丛书名称 | Methods in Molecular Biology |
| 图书封面 |  |
| 描述 | .This volume covers the techniques necessary for a successful fragment-based drug design project, beginning from defining the problem in terms of preparing the protein model, identifying potential binding sites, and the consideration of various candidate fragments for simulation. The second part discusses the technical aspects that various methods have used to simulate fragment binding to a target protein by using Monte Carlo, molecular dynamics, and docking algorithms. After simulations, fragments are assembled into molecules using a variety of approaches, which are explored next. A discussion of design strategies and consideration of drug-like properties is included as part of the design process at this stage. Finally, several examples of successful fragment-based drug design projects are presented. Written for the .Methods in Molecular Biology. series, this work contains the kind of detailed description and implementation advice to encourage success in the lab..Practical and cutting-edge, .Fragment-Based Methods in Drug Discovery. takes into account the great accomplishments in the field to provide an ideal guide for researchers continuing to investigate this exciting area of ph |
| 出版日期 | Book 2015 |
| 关键词 | Binding site identification; Computational resources; Drug design; Fragment binding; Protein model prepa |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4939-2486-8 |
| isbn_softcover | 978-1-4939-4614-3 |
| isbn_ebook | 978-1-4939-2486-8Series ISSN 1064-3745 Series E-ISSN 1940-6029 |
| issn_series | 1064-3745 |
| copyright | Springer Science+Business Media New York 2015 |
发表于 2025-3-21 17:25:55
