,Purification of Caveolae-Derived Membrane Microdomains Containing Lipid-Anchored Signaling Molecules, Such as GPI-Anchored Proteins, H-Ras, Src-Family Tyrosine Kinases, eNOS, and G-Protein α-, β-, anThis laboratory is interested in understanding how signaling molecules are compartmentalized within normal cells, and how this molecular organization may be disrupted during oncogenic transformation. For this purpose, the authors have focused their efforts on a particular organelle, or subcompartment of the plasma membrane, known as caveolae (.). |