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Interactions of Differentiation Inducing Agents In Vitro Provide Insight into Molecular Mechanisms ote the therapeutic potential of these agents, little is known about their mechanisms of action. Agents enhancing differentiation to the neutrophil-granulocyte lineage include retinoids, polar-planar compounds such as dimethylsulphoxide (DMSO) and N-methylformamide (N-MF), DNA synthesis inhibitors (D

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Immunological and Molecular Classification of Human Leukemiasan leukemia cells. In this study we report our findings, using this combined approach, in the different forms of acute and chronic leukemia. All cases of common acute lymphoblastic leukemia (cALL) studied showed (with only one exception) a heavy chain Ig gene rearrangement; a light chain gene reorga

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Response to an Active Vitamin D3 Metabolite of Transplantable Human Myeloid Leukemic Cell Lines in Aula except KG-1 consistently grew nonmet-astatic subcutaneous (sc) tumors after 3 weeks. Cytologic, immuno- and enzyme-cytochemical tests proved identity of respective tumor and cultured cells. Adenosine triphosphatase (ATPase) reactivity was limited to tumorigenie cells in vivo, while leucine amino

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Risk Factors for Acute Graft-vs-Host Disease in Humansory cause of death in 15–40% in most series. GVHD is believed to be caused by donor T-lymphocytes that recognize and react against disparate antigens on host tissues. When donors and recipients are identical at the major histocompatability complex, minor histocompatability or other alloantigens are

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Thymic Hormones in Thymus Recovery from Radiation Injuryificantly the responses of thymic cells to IL-1 in 107#x2013;13 weeks old C57Bl/KsJ, C3H/HeJ, and DBA/1 mice. Older mice, 5 months or more in age, of DBA/1 strain did not respond to treatment with TF5. However, C3H/HeJ mice of the same age were highly responsive. In conclusion, (a) cells repopulatin

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Early Biochemical Steps in Colony Stimulating Factor (CSF) Generation are Induced by Synergy betweenF by measuring .H-thymidine incorporation into a CSF dependent basophil/mast cell line, PT-18. TPA and A23187 acted cooperatively to stimulate generation of CSF similar to the action of TPA and LPS. In addition, trimethoxybenzoate (TMB-8), an inhibitor of calcium mobilization, inhibited CSF producti

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