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Characterization of Bone Marrow and Lymph Node Repopulating Cells by Transplanting Mononuclear Cellshologic and functional tests have been employed in an endeavor to accomplish this task. Multipotential stem cells are known to be present in blood because of the complete and lasting regeneration of hemopoiesis induced by transfusion of leukocyte suspensions collected from blood by leukocytopheresis

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Concepts and Observations on the Regulation of Granulocyte Productiones normal within 6 hr after induction of bacterial pneumonia in dogs. Furthermore, the ratio of nonsegmented to segmented neutrophils increased progressively, showing a rapid release from the bone marrow of less mature cells. Under normal steady-state conditions there are modest fluctuations in the

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The Regulatory Role of the Macrophage in Normal and Neoplastic Hemopoiesissolid medium when provided with stimulatory macromolecules operationally termed colony-stimulating factor (CSF) (3, 26, 35). A similar if not identical class of molecules also stimulates the proliferation of a precursor cell solely committed to macrophage differentiation, the colony-forming unit-per

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Humoral Regulation of Eosinophil Granulocytopoiesis problem. Stimulators for the initiation of granulocytosis are ubiquitious, resulting in uncontrolled and undesirable variables. Increased medullary granulocytopoiesis can usually be demonstrated following leukemoid reactions, regardless of the stimulus. Techniques for the reproducible quantitation

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Some Characteristics of in Vitro Erythroid Colony and Burst-Forming Unitsopoiesis-stimulating properties in experimental animals. The target cells of EP are operationally termed erythropoietin-responsive cells (ERC) (6). They are considered to be primitive hemopoietic cells, not morphologically recognizable as erythroid, and induced by EP to form hemoglobin (16). ERC, in