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Ladoga and Onego - Great European Lakese of genotype .. (Steel, Steel-Dickie mutant mice) suffer a chronic macrocytic anemia, and are extremely sensitive to ionizing radiation (11). Previously, it was hypothesized that the genetic defect disturbs erythropoiesis very early in the erythron, perhaps at the point of commitment of . colony-fo

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Art Pop: The Styles of Lady Gaga,rse. Colony assays have now been described for pluripotent stem cells (20), granulocyte and macrophage progenitors (3, 10, 13, 16), erythropoietic progenitors (1, 18), megakaryocyte precursors (12, 15), B- and T-lymphocyte precursors (5, 14, 17), and cells in leukemic marrow (4). For all the above c

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https://doi.org/10.1007/978-3-319-76611-9opoiesis-stimulating properties in experimental animals. The target cells of EP are operationally termed erythropoietin-responsive cells (ERC) (6). They are considered to be primitive hemopoietic cells, not morphologically recognizable as erythroid, and induced by EP to form hemoglobin (16). ERC, in

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Lady Macbeth in the White House,sis and maintenance of the integrity of the blood vasculature. Platelet production is dependent upon the steady supply of megakaryocytes, which are themselves incapable of cellular proliferation, being almost exclusively in a state of cytoplasmic maturation (14). The production of megakaryocytes is

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Weitere Untersuchung der Viergelenkkette,e differentiated compartment (Fig. 1). The pluripotent stem cells as represented by the colony-forming unit-spleen (CFU-s) have the physiologic capabilities of self-renewal and control of compartment size, which are normal requirements of precursor cells (30). Regulation of this compartment is assum

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https://doi.org/10.1007/978-3-662-38548-7s in semisolid agar cultures (1, 22), has been detected in many biologic fluids (8, 23–26, 30). Most of the sources of GM-CSF are unsuitable for the isolation of this factor and only human urine (30), mouse L-cell-conditioned medium (8, 28), and mouse lung-conditioned medium (MLCM) (23–26) appear to

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An Immunologic Approach to Cell Cycle Analysis of the Stem Cellial and essential step in the development of our capabilities to obtain definitive answers to these fundamental biologic problems. For the hematopoietic system, the colony assay technique introducted by Till and McCulloch (27) for pluripotent stem cells or CFU-s, the in . assays for unipotent myeloi