Titlebook: Emerging Neurobiology of Antidepressant Treatments; Michael Browning,Philip J. Cowen,Trevor Sharp Book 2024 The Editor(s) (if applicable)

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Emerging Neurobiology of Antidepressant Treatments

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SSRIs in the Treatment of Depression: A Pharmacological CUL-DE-SAC?,ficacy, at the cost of a greater side-effect burden. Attempts to supplement serotonin reuptake activity with actions at serotonin receptor sub-types have not yet yielded substantial benefits; however, vortioxetine may provide more utility in the management of cognitive impairment. Future advances mi

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Opioid Mechanisms and the Treatment of Depression,standing of the diverse mechanisms through which opioid system modulation may improve depressive symptoms could ultimately aid in the development of safe and effective alternative treatments for individuals with difficult-to-treat depression.

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Microbiota-Gut-Brain Axis and Antidepressant Treatment,ing deficits in catecholaminergic and monoamine neurotransmission. Interestingly, there is evidence to suggest that antidepressants may play a role in modulating the gut microbiota, thereby possibly having an impact on the microbiota-gut-brain axis in this manner. The development of prebiotics, prob

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