Titlebook: Extracellular Matrix Protocols; Charles H. Streuli,Michael E. Grant Book 20001st edition Springer Science+Business Media New York 2000

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Principles of Treatment: Decision Making,tructure, and function. However, their primary structures have revealed that their polypeptide components are frequently comprised of a series of sequence repeats or “modules” (.). This mosaic nature of ECM macromolecules permits their properties to be analyzed by a “dissection” strategy (.), where

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https://doi.org/10.1007/978-94-009-4135-9ion, cell migration, proliferation, differentiation, and gene expression (.,.). Integrins in their native environment can diffuse in the plane of the membrane, and this mobility is required for processes like the assembly of integrins to focal contacts or cell migration (.,.).

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Clinical Topics in Infectious Diseasey mild to severe and lethal forms (.-.). There are over 100 unique well-characterized chondrodysplasia phenotypes and remarkable progress has been made in the last few years identifying the underlying genetic basis of many of these disorders (.). In most cases, a molecular genetics approach was empl

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Hepatitis C Virus-Associated Cancers,t phenotypic overlaps, like the genodermatoses. Homologous gene targe ing in embryonic stem (ES) cells is increasingly favored over the transgen approach because it allows the study of mutations in homozygosity and without altering the remainder of the genome (1). Homologous gene targeting has been

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Conclusions: Are We There Yet?,s, expression of ECM genes is regulated temporally and spatially. Identification of regulatory elements that direct tissue- and stage-specific expression is important for understanding of the role of ECM genes in cellular differentiation and function. A significant number of ECM genes have been clon

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Frank J. Jenkins,Linda J. Hoffmanal analysis of protein can be studied by suppression of gene expression, thus introducing a plasmid which expresses an antisense RNA in mammalian cells. Several extracellular matrix proteins require an assembly of subunits to form functional heteromultimers with distinct features. Thus, expression o