Titlebook: Extracellular ATP and adenosine as regulators of endothelial cell function; Implications for hea Evgenia Gerasimovskaya,Elzbieta Kaczmarek

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Anthony J. Mahler,John Friedlandmore, our results demonstrate that connexin43 hemichannels provide the pathway for ATP release. Our experiments show that the paracrine IC is strongly reduced in the presence of inflammatory agents, such as histamine and thrombin, that enhance actomyosin contraction. The effect of these agents is du

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Nucleotides and Novel Signaling Pathways in Endothelial Cells: Possible Roles in Angiogenesis, Endoing through P2 receptors may exert anti-inflammatory, anti-oxidative, pro-proliferative, and anti-apoptotic effects in the endothelium. Sustaining of eNOS activation in ECs exposed to high glucose concentrations supports our hypothesis that extracellular nucleotides play a protective role against en

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Extracellular Purines in Endothelial Cell Barrier Regulation,upled receptors (GPCR). Selective activation of endothelial purinoreceptors responsible for barrier protection might form a basis for the treatment of various disorders. The therapeutic potential of purinoreceptors is rapidly expanding field in pharmacology and some selective agonists became recentl

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The P2Y2 Nucleotide Receptor in Vascular Inflammation and Angiogenesis,e up-regulation of VCAM-1. The P2Y.R also contains an arginine-glycine-aspartate domain that mediates interactions with α.β./β. integrins that enable nucleotides to increase cell migration, an important event in inflammation and tumor angiogenesis. Taken together, these findings indicate that P2Y.Rs

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ATP Release Via Connexin Hemichannels Controls Intercellular Propagation of Ca2+ Waves in Corneal Emore, our results demonstrate that connexin43 hemichannels provide the pathway for ATP release. Our experiments show that the paracrine IC is strongly reduced in the presence of inflammatory agents, such as histamine and thrombin, that enhance actomyosin contraction. The effect of these agents is du