Titlebook: Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy; Divya Vohora Book 2021 Springer Science+Bu

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Book 2021oratory. .Cutting-edge and practical, .Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy. is a valuable resource for researchers, in both industry and academia, interested in learning about this important and developing field..

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Zoltan Acs,László Szerb,Erkko Autiotients with hippocampal sclerosis, the most common DRE pathology using patch clamp electrophysiology. Our aim is to provide a guideline on how to apply the cellular electrophysiological methods to study altered synaptic transmission associated with DRE and its application to identify drug-resistant epileptogenic network.

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Global Environmental Changes in South Asiaing as well as provide an outline of the key components of the recording system, including housing, that are needed to perform the studies. In addition, we offer suggestions what precautions are necessary and the potential technical and interpretive pitfalls.

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J. John Sepkoski Jr.,Carl F. Kochns of both assay and the animal model. In addition, we give examples of how the assay can be used to determine pathogenicity in epilepsy-associated genetic variants, to screen for anticonvulsants, and to identify AED mechanisms of action.

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Protocol for Rodent Organotypic Hippocampal Slice Culture Model for Ex Vivo Monitoring of Epileptogeses different aspects of the epileptogenesis process in a compressed time scale such that within 7 days, cultures become spontaneously epileptic. Here, in this chapter, we seek to elucidate and describe several methodologies that can be utilized to study epileptogenesis in vitro.

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Cellular Electrophysiological Methods to Decipher the Altered Synaptic Transmission Associated with tients with hippocampal sclerosis, the most common DRE pathology using patch clamp electrophysiology. Our aim is to provide a guideline on how to apply the cellular electrophysiological methods to study altered synaptic transmission associated with DRE and its application to identify drug-resistant epileptogenic network.

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Models of Seizures and Epilepsy: Important Tools in the Discovery and Evaluation of Novel Epilepsy TSince the discovery of phenytoin in the 1930s, almost all antiseizure drugs (ASDs) have been identified by their effects in animal models, and millions of patients have profited from the successful translation of animal data into the clinic. However, several unmet clinical needs remain, including re