Titlebook: Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy; Divya Vohora Book 2021 Springer Science+Bu

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A Method to Induce Lamotrigine-Resistant Corneal Kindled Miced recording electrodes and the large size of rats that prohibits the early evaluation of investigational compound libraries. Furthermore, despite the more than 20 ASMs on the market today, nearly 30% of patients with epilepsy remain resistant to these currently available medications. To address this

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Book 2021for ex vivo and in vitro experimental models and widely-used in vivo (acute and chronic seizure) models in epilepsy research. Chapters also cover techniques to screen the effective leads for the treatment of refractory seizures of pharmacoresistant epilepsy and invertebrate, non-mammalian models. In

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Models of Seizures and Epilepsy: Important Tools in the Discovery and Evaluation of Novel Epilepsy Tprevent development of epilepsy in patients at risk following brain injury. This minireview, which serves as an introduction to the Neuromethods volume ., briefly introduces the challenges and opportunities for in vivo and in vitro models of seizures and epilepsy and how such models may help to develop the next generation of drug therapies.

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