Titlebook: Experimental and Clinical Effects of L-Asparaginase; International Sympos E. Grundmann,H. F. Oettgen Book 1970 Springer-Verlag Berlin • Hei

LUDE

死亡率

The Distribution and Clearance of L-Asparaginasecells has been the subject of numerous presentations at this symposium. The purpose of this report is to describe an automated method for the assay of L-asparaginase and to present data concerning the distribution and clearance of administered L-asparaginase.

搬运工

Critical Influence of an Enzyme-Elevating Virus upon Long-Term Remissions of Mouse Leukemia Followince of a non-cytopathic, and otherwise benign replicating agent as an adjunct in asparaginase therapy was somewhat unexpected and to our knowledge has no theoretical antecedent. This virus is variously known as the lactate dehydrogenase-elevating virus, the LDH-virus, the enzymes-elevating virus and by other designations [65, 671].

燕麦

Studies on the Glutaminase Activity of E. coli Asparaginase in Tissue Culturee lost the ability to synthesize L-asparagine and thus depend on the exogenous supply of this amino acid. Yet it is not always sufficiently considered that E. coli asparaginase also possesses a small amount of L-glutaminase activity [1] and in high dosage may become effective by depriving the cells of L-glutamine.

高脚酒杯

裁决

Influence of L-Asparaginase Preparations of E. coli and Agouti Serum on the Homograft Reactivity in in mice treated with high doses of the enzymepreparation. . described inhibition of the graft-versus-host reaction in mice and rats receiving E. coli L-asparaginase [8]. Suppression of phytohemagglutinin-induced transformation of human lymphocytes was reported by . et al. [1] and by . [12].

opportune

全神贯注于

yohimbine

Experimental Investigations on Problems of the Clinical Use of L-Asparaginaseuseful to study experimentally problems which arose from the clinical use of the enzyme. Consequently we investigated the influence of the following factors on tumor inhibition: dosage, duration of treatment, treatment schedules, treatment of Crasnitin resistant tumors, combined treatment with Crasnitin, and immunological factors in enzyme therapy.

索赔

https://doi.org/10.1057/9780230228436 reversibility of the antileukemic effect of A-ase . and ., the effects of dose and dosage schedule on early and advanced ascitic, subcutaneous, and intracerebral leukemia, and the effect of prior or concomitant treatment with other chemotherapeutic agents on both the half-life of the drug and the i