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Titlebook: Experimental and Clinical Effects of L-Asparaginase; International Sympos E. Grundmann,H. F. Oettgen Book 1970 Springer-Verlag Berlin • Hei

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Sheldon, Pastor and His People,] and are predominantly of lymphatic or hematopoeitic origin. Rarely, other tumor types, including a rat fibrosarcoma [8], a mouse mammary carcinoma [15], and two cases of human malignant melanoma [6, 12] may be suppressed by treatment with asparaginase.
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Gilbert and Sullivan‘s ‘Respectable Capers‘ host reactions to this disease (. et al., 1969). In these studies the patient’s own serum was added to the tumour cells . and the existence of complement-dependent autoantibodies to some melanomas was demonstrated. To test if melanoma cells were sensitive to L-asparaginase, the cells were treated i
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Travelling Inwards: D. H. Lawrence, in mice treated with high doses of the enzymepreparation. . described inhibition of the graft-versus-host reaction in mice and rats receiving E. coli L-asparaginase [8]. Suppression of phytohemagglutinin-induced transformation of human lymphocytes was reported by . et al. [1] and by . [12].
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Deleuze and the Film in His Mindce of resistance in mice bearing a leukemia which is sensitive to the drug (. and ., 1969) (personal unpublished findings); secondly, L-asparaginase shows immunosuppressive activities in a number of tests.
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Sheldon, Pastor and His People,e lost the ability to synthesize L-asparagine and thus depend on the exogenous supply of this amino acid. Yet it is not always sufficiently considered that E. coli asparaginase also possesses a small amount of L-glutaminase activity [1] and in high dosage may become effective by depriving the cells of L-glutamine.
发表于 2025-3-26 15:45:30 | 显示全部楼层
Sheldon, Pastor and His People,] and are predominantly of lymphatic or hematopoeitic origin. Rarely, other tumor types, including a rat fibrosarcoma [8], a mouse mammary carcinoma [15], and two cases of human malignant melanoma [6, 12] may be suppressed by treatment with asparaginase.
发表于 2025-3-26 18:59:55 | 显示全部楼层
Travelling Inwards: D. H. Lawrence, in mice treated with high doses of the enzymepreparation. . described inhibition of the graft-versus-host reaction in mice and rats receiving E. coli L-asparaginase [8]. Suppression of phytohemagglutinin-induced transformation of human lymphocytes was reported by . et al. [1] and by . [12].
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