Titlebook: Experimental Metastasis: Modeling and Analysis; Anastasia Malek Book 2013 Springer Science+Business Media Dordrecht 2013 cancer.in vitro m

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Malignant Pleural Effusion,n experimental modeling of MPE indicate that tumor-induced inflammation, angiogenesis, and vascular hyperpermeability critically drive MPE formation independent from anatomical blockade of pleural fluid turnover. In this regard, different research groups have established novel experimental models mi

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János Haas,András Nagymarosy,Géza Hámorins incomplete and is likely necessary to develop suitable therapies. Towards this goal, in this chapter we describe the process of metastasis, liver anatomy and function, and models of liver metastasis and analysis.

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Breast Cancer Invasion and Metastasis,c disease. In breast cancer, malignant cells disseminate through lymphatic or hematogenous routes to distant organs. Over the last decades, the 5-year survival of breast cancer has increased due to early screening and advanced local and systemic treatments. Understanding the fundamental biology unde

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Brain Metastasis,ticularly those with advanced melanoma, lung and breast cancer. As systemic therapies improve for other cancer types, relapse to the CNS is likely to rise as a sanctuary site presumably due to the inability of presently available drugs to cross the blood-brain barrier (BBB). Patients at risk would t

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Pulmonary Metastasis,tanding of the molecular mechanisms underlying pulmonary colonization by circulating cancer cells could improve the quality of life and survival rate for patients. It definitely requires well-designed experimental systems..This chapter presents a short review of the main biological aspects of pulmon

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Liver Metastases,ic site. As a vital organ with a number of varied functions, organ damage due to metastatic disease is associated with profound morbidity and mortality. The multiple functions, large blood volume as well as the unique anatomy (dual blood supply, fenestrated endothelium and sinusoids) of the liver pl