Titlebook: Excitotoxins; Kjell Fuxe,Peter Roberts,Robert Schwarcz Book 1983 Palgrave Macmillan, a division of Macmillan Publishers Limited 1983 biolo

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Two Types of Excitatory Amino Acid Responses in the Cat Caudate Nucleus were applied by microiontophoresis. The agonists exhibited two types of responses, both of which consisted of gradual membrane depolarizations; however, in type 1 this was associated with repetitive, relatively regular firing, whereas in type 2 action potentials generally occurred on additional abr

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Alteration by Kainate of Energy Stores and Neuronal-Glial Metabolism of Glutamate amate and aspartate from the tissue and decreased the synthesis of glutamine from a variety of radioactive precursors. These effects were attributed to alterations in glial cells secondary to massive depolarization of neurons. These results and those of others are discussed in terms of their implica

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Excitotoxins: An Overviewfor the effort spent in pursuing these challenges. If we are right in suspecting that endogenous excitotoxins--glutamate (Glu), aspartate (Asp) and perhaps others--are the neurotransmitters released at the majority of excitatory synapses in the mammalian CNS, this is reason enough for our intrigue w

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Kainic Acid: Insights Into Its Receptor-Mediated Neurotoxic Mechanismsrmationally restricted analogue of L-glutamate, it was a potent agonist at glutamate receptors (Olney et al., 1974; Coyle and Schwarcz, 1976). Since the first reports of the perikaryal-specific neurotoxic action of intracerebrally injected KA, it has become increasingly apparent that the mechanism o

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Studies On Excitatory Amino Acid Receptors And Their Interactions And Regulation Of Pre- And Postsyn membranes. Kainic acid (10. M) in vitro rapidly reduces the number (11 %) and increases the affinity (12%) in the striatal .H-glutamate binding sites, while glutamate (10. M) in vitro increases the number of striatal .H-kainic acid binding sites (18 %) and reduces their affinity (46%). The specific

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Electrophysiological And Pharmacological Studies On Kainic Acid-Induced Neuronal Activationme sensitivity of CA. pyramidal hippocampal neurons to the neurotoxic action of kaïnic acid (KA), these neurons were found to be exquisitely sensitive to the excitatory action of KA applied microiontophoretically. The excitatory action of KA on CA. but not on CA. neurons was selectively antagonized

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The Role Of Seizures In Kainic Acid Induced Brain Damagen "distant” structures in particular in the hippocampal formation and other limbic structures. There is now good evidence that the in adequate experimental conditions the distant damage is largely due to the spread of paroxysmal discharge and not to a direct action of the toxin (by diffusion). The u