Titlebook: Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics; 11th European Confer Leonardo Vanneschi,William S. Bush,Mario

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Mining for Variability in the Coagulation Pathway: A Systems Biology Approachent scenarios, we perform them using High Performance Computing. We analyze different settings for model representing the cases of “healthy” and different “unhealthy” subjects, comparing and testing their variability in order to gain valuable biological insights.

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Leonardo Vanneschi,William S. Bush,Mario GiacobiniState-of-the-art research.Fast-track conference proceedings.Unique visibility

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Solidarity in the European Union,hese interactions with high accuracy and in time linear in the number of genes. Our algorithm is an improvement over the SURF* algorithm, which detects genetic signals by comparing individuals close to, and far from, one another and noticing whether differences correlate with different disease statu

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Belgium: Struggling with Solidarityeffectively identify and summarize gene-gene relationships within individual experiments. For gene-expression datasets, the Pearson correlation is often applied to build coexpression networks because it is both easily interpretable and quick to calculate. Here we develop and evaluate weighted Pearso

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‘Centre’ and ‘Periphery’ in Europer 600 physical attributes, diseases, and behavioral traits; based on more than 6,000 genetic variants (SNPs) from Genome-Wide Association Studies data. Using phenotype-to-SNP associations, and HapMap project data, we link traits based on the common patterns of human genetic variations, expanding pre

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Automotive Industry & Manufacturing,nging due to a lack of statistical power in most feasibly sized datasets. Several statistical tests have been developed to either collapse multiple rare variants from a genomic region into a single variable (presence/absence) or to tally the number of rare alleles within a region, relating the burde

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Kim Toft Hansen,Steven Peacock,Sue Turnbull reproduction. Many explanations have been proposed to explain the benefits of sex, including the role of recombination in maintaining diversity and the elimination of detrimental mutations, the advantage of sex in rapidly changing environments, and the role of spatial structure, finite population s

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Frédéric Durand,Antoine Decovillelving optimization problems. One important optimization problem in Bioinformatics is the Motif Discovery Problem (MDP), applied to the specific task of discovering DNA patterns (motifs) with biological significance, such as DNA-protein binding sites, replication origins or transcriptional DNA sequen