Titlebook: Eukaryotic Transcriptional and Post-Transcriptional Gene Expression Regulation; Narendra Wajapeyee,Romi Gupta Book 2017 Springer Science+B

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陈腐思想

Pigeon

Profiling Changes in Histone Post-translational Modifications by Top-Down Mass Spectrometry,mutant fungal species. The proteoforms exhibiting differential abundances can be subjected to further targeted studies by other MS or orthogonal (e.g., biochemical) assays. This method can be generally adapted for screening of changes in histone modifications between samples such as wild type vs. mutant or healthy vs. diseased.

幼稚

Large-Scale RNA Interference Screening to Identify Transcriptional Regulators of a Tumor Suppressoror suppressor gene, using RASSF1A as an example. The approach we describe is a general RNAi screening strategy that can be applied to identify other factors that drive and/or maintain epigenetic modifications on specific genes, including cancer-related genes.

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AORTA

集聚成团

舔食

TOXIN

Systematic Discovery of Chromatin-Bound Protein Complexes from ChIP-seq Datasets,r, transcription factors rarely bind chromatin alone but often bind together with other cofactors, forming protein complexes. Here, we describe a computational method that integrates multiple ChIP-seq and RNA-seq datasets to discover protein complexes and determine their role as activators or repres

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