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Titlebook: Eukaryotic Cell Function and Growth; Regulation by Intrac Jacques E. Dumont,Barry L. Brown,Nicholas J. Marsh Book 1976 Springer Science+Bus

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Hormone Binding to Receptors: Vasopressin,denylate cyclase present in the tubular cells from the responding parts of the nephron (1, 2). Membrane fractions prepared from the kidney medullary portion contain a vasopressin- sensitive adenylate cyclase (3–8); they exhibit the expected high sensitivity to the hormone and marked stereospecificit
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Regulation of Cyclic AMP Phosphodiesterase Activity,controls the rate of cyclic AMP formation, and by altering the activity of the phosphodiesterases which convert cyclic AMP to 5’-AMP.. Conceivably, control could also be exerted through processes related to extrusion of cyclic AMP from the cells or through enzymes that might catalyze the conversion
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Theoretical Simulation of the cAMP System,ge that it is now very difficult to integrate the data into a single model. There is therefore an urgent need for a systematic theoretical study of the basic questions of “why” and “how” for each of the main subsystems of the intricate reaction network which operates in the living cell.
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Cyclic AMP and Cyclic GMP Binding in Tissues,intracellular sites, capable of binding cyclic AMP (1, 2). These cyclic AMP binding fractions were considered to be involved in the action of the cyclic nucleotide. Then, following the first discovery by Walsh .. (3) that certain protein kinases could be directly activated by cyclic AMP, Kuo and Gre
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