Titlebook: Epigenome-Wide Association Studies; Methods and Protocol Weihua Guan Book 2022 Springer Science+Business Media, LLC, part of Springer Natur

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https://doi.org/10.1007/b101439 mediation effects only involve selected (gene-specific) candidate methylation markers. There is an urgent need for appropriate analytical methods for EWAS mediation analysis. In this chapter, we provide an overview of recent advances on high-dimensional mediation analysis, with application to two DNA methylation data.

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Designing Processes and Activities,tion between batches have been developed either by correcting based on known batch factors or by estimating directly from the output data. In this chapter, we will review and demonstrate several popular methods for batch effect correction and make practical recommendations in epigenome-wide association studies (EWAS).

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https://doi.org/10.1007/978-3-031-22669-4ental exposures. This chapter summarizes several large-scale epigenome-wide association studies (EWAS) on asthma and other allergic diseases and draws a blueprint for future analysis and research direction.