Titlebook: Epigenome-Wide Association Studies; Methods and Protocol Weihua Guan Book 2022 Springer Science+Business Media, LLC, part of Springer Natur

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Meta-Analysis for Epigenome-Wide Association Studies,avy burden of multiple testing of hundreds of thousands of DNA methylation markers, individual studies often have limited sample sizes and power. The EWAS meta-analysis is an approach that combines results from multiple studies on the same scientific question. It helps to improve statistical power b

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A Review of High-Dimensional Mediation Analyses in DNA Methylation Studies,wide DNA methylation data (EWAS) have become the new standard for epigenetic studies in human populations. However, to date most epigenetic studies of mediation effects only involve selected (gene-specific) candidate methylation markers. There is an urgent need for appropriate analytical methods for

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DNA Methylation Imputation Across Platforms,(PFR) method we have previously developed. We will start with a brief review of DNA methylation, genomic and epigenomic contexts where imputation has proven beneficial in practice, and statistical or computational methods proposed for DNA methylation in the recent literature (Subheading .). The rest

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Workflow to Mine Frequent DNA Co-methylation Clusters in DNA Methylome Data,n a daily basis, which in turn calls for the development of powerful bioinformatics tools and efficient workflows to analyze them. One of the approaches to address the “big data” issue is to mine highly correlated clusters/networks of biological molecules, which may provide rich yet hidden informati

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Application of Correlation Pre-Filtering Neural Network to DNA Methylation Data: Biological Aging P 20,000 top correlated DNA methylation features and trained by 1810 healthy samples from GEO database. The input data format and the instructions for parser and . model are detailed in this chapter. Followed by two potential uses, age acceleration detection and unknown age prediction are discussed.

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Book 2022cible analysis pipelines, and tips on troubleshooting and avoiding known pitfalls... .Authoritative and cutting-edge, .Epigenome- Wide Association Studies: Methods and Protocols: .aims to be a useful practical guide to researches to help further their study in this field. .