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Titlebook: Epigenetics: Development and Disease; Tapas K. Kundu Book 2013 Springer Science+Business Media Dordrecht 2013 Cancer and diabetes.Chromati

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书目名称Epigenetics: Development and Disease
编辑Tapas K. Kundu
视频video
概述Role of genome organisation as a basic platform of different epigenetic phenomena in the pathophysiological context.Epigenetic regulation of transcription Epigenetic contribution in development.Epigen
丛书名称Subcellular Biochemistry
图书封面Titlebook: Epigenetics: Development and Disease;  Tapas K. Kundu Book 2013 Springer Science+Business Media Dordrecht 2013 Cancer and diabetes.Chromati
描述Epigenetics is the phenomenon which fine tunes the processes associated with life, beyond that which is specified by the sequence of the genetic material; DNA. The covalent modification of DNA, DNA associated histones, several non histone proteins as well as non coding RNA coherently operate to establish the epigenetic regulation of gene expression in physiological and pathophysiological conditions. This volume presents contributions from worldwide experts presenting their research and findings, including: the evolution of epigenetic machineries from archaea to higher eukaryotes; role of epigenetics in development and transcription regulation; epigenetic landscape of human disease; a chemical biology approach to understanding epigenetic phenomena; exploration of different small molecules as epigenetic therapies.This volume is aimed at students and researchers of chromatin biology and epigenetics and will also be of interest to a broader pharmaceutical audience.
出版日期Book 2013
关键词Cancer and diabetes; Chromatin dynamics; Epigenetic therapy; Gene expression; Stem cell differentiation
版次1
doihttps://doi.org/10.1007/978-94-007-4525-4
isbn_softcover978-94-017-7996-8
isbn_ebook978-94-007-4525-4Series ISSN 0306-0225 Series E-ISSN 2542-8810
issn_series 0306-0225
copyrightSpringer Science+Business Media Dordrecht 2013
The information of publication is updating

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Secondary Structures of the Core Histone N-terminal Tails: Their Role in Regulating Chromatin Structhe crystal. This suggested that the tails contributed minimally to chromatin structure. However, . studies have shown that the tails were involved in a range of intra- and inter-nucleosomal as well as inter-fibre contacts. The H4 tail, which is essential for chromatin compaction, was shown to contac
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Role of DNA Methyltransferases in Epigenetic Regulation in Bacteriaeneration to generation with no alterations in the DNA sequence and represent the epigenetic signal in prokaryotes. DNA methyltransferases are enzymes involved in DNA modification and thus in epigenetic regulation of gene expression. DNA methylation not only affects the thermodynamic stability of DN
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Metabolic Aspects of Epigenome: Coupling of ,-Adenosylmethionine Synthesis and Gene Regulation on Chup. SAM is biosynthesized by methionine adenosyltransferase (MAT) using two substrates, methionine and ATP. Three distinct forms of MAT (MATI, MATII and MATIII), encoded by two distinct genes (. and .), have been identified in mammals. MATII consists of α2 catalytic subunit encoded by . and β regula
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Small Changes, Big Effects: Chromatin Goes Aging0). Efforts to understanding the mechanisms that extend or shorten lifespan have been made since the early twentieth century. Aging is characteristically associated with a progressive decline in the overall fitness of the organism. Several studies have provided valuable information about the molecul
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Basic Mechanisms in RNA Polymerase I Transcription of the Ribosomal RNA Genesng many fundamental cellular processes. Extensive research into the mechanisms governing transcription by Pol I has revealed an intricate set of control mechanisms impinging upon rRNA production. Pol I-specific transcription factors guide Pol I to the rDNA promoter and contribute to multiple rounds
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