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Titlebook: Epigenetics, Brain and Behavior; Paolo Sassone Corsi,Yves Christen Book 2012 Springer-Verlag Berlin Heidelberg 2012 DNA methylation.Nucleo

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书目名称Epigenetics, Brain and Behavior
编辑Paolo Sassone Corsi,Yves Christen
视频video
概述The focus of this volume is on critical epigenetic regulation and chromatin remodeling events that occur in the nervous system.On the presumed mechanisms that operate within neurons to translate them
丛书名称Research and Perspectives in Neurosciences
图书封面Titlebook: Epigenetics, Brain and Behavior;  Paolo Sassone Corsi,Yves Christen Book 2012 Springer-Verlag Berlin Heidelberg 2012 DNA methylation.Nucleo
描述Recent years have seen spectacular advances in the filed of epigenetics. These have attracted the interest of researchers in many fields and evidence connecting epigentic regulation to brain functions has been accumulationg. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. A variety of studies have centered on the molcular mechanisms implicated in epigentic control and how these may operte in concert. It will be critical to unravel how specifity is achieved. The focus of this volume is on critical epigenetic regulation and chromatin remodeling events that occur in the nervous system and on the presumed mechanisms that operate within neurons to translate them into long-lasting neuronal responses.
出版日期Book 2012
关键词DNA methylation; Nucleosome remodelling; circadian system; epigenetic control; memory formation; neuronal
版次1
doihttps://doi.org/10.1007/978-3-642-27913-3
isbn_softcover978-3-642-44108-0
isbn_ebook978-3-642-27913-3Series ISSN 0945-6082 Series E-ISSN 2196-3096
issn_series 0945-6082
copyrightSpringer-Verlag Berlin Heidelberg 2012
The information of publication is updating

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Jong Hyun Kim,Jung Min Han,Sunghoon Kimeview the emerging evidence for epigenetics as a candidate mechanism for these effects. Epigenetics refers to functionally relevant modifications to the genome that do not involve a change in nucleotide sequence. Such modifications include chemical marks that regulate the transcription of the genome
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https://doi.org/10.1007/978-3-642-68579-8s involve the specific marking of DNA and protein histones, which provides a potent and dynamic mode of regulation of the genome without changing the DNA sequence itself. In mammals, the epigenome was previously thought to be fully erased after fertilization and then partly reestablished for further
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Allen Taylor,David Sanford,Thomas Nowelle proteins. These modifications facilitate the assembly of protein complexes that regulate gene expression in a highly orchestrated fashion. The importance of epigenetic regulators in brain development and function is supported by the strong association between mental retardation in humans and the a
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https://doi.org/10.1057/978113708065301, 1984). Although the response to this idea was relatively modest at the time, 20 years later it was shown that histone acetylation, a common form of epigenetic modification, was dynamically altered during memory formation (Levenson et al. J Biol Chem 279:40545–40559, 2004). Histone acetylation is
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