| 书目名称 | Epigenetic Therapy of Cancer |
| 副标题 | Preclinical Models a |
| 编辑 | Michael Lübbert,Peter A. Jones |
| 视频video | |
| 概述 | Devotes detailed attention to the translation of basic research and drug development to clinical applications in the treatment of solid tumors as well as hematologic malignancies and hemoglobinopathy. |
| 图书封面 |  |
| 描述 | The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail. |
| 出版日期 | Book 2014 |
| 关键词 | Carcinoma; Chromatin; DNA Methylation; Histone Organisation; Myelodysplasia; gene therapy |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-642-38404-2 |
| isbn_softcover | 978-3-662-51928-8 |
| isbn_ebook | 978-3-642-38404-2 |
| copyright | Springer-Verlag Berlin Heidelberg 2014 |
发表于 2025-3-21 19:00:37
