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Titlebook: Epidemiology of Human Congenital Malformations; Bengt Källén Book 2014 Springer International Publishing Switzerland 2014 Birth defect.Con

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Statistical Considerations,Statistical considerations include discussions of study power, of the significance of confounders and how adjustment for confounders are made, mass significance and the meaning of p values, lumping or splitting. A summery is given of the statistical methods used in the book.
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Severe Eye Malformations,Various types of severe eye malformations existed in 439 children, 198 of them had a congenital cataract. Infants of women born outside Sweden had an increased risk; except for this no maternal risk factor including drug use could be identified.
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Malrotation of the Gut,Infants with a malrotation (n= 206) were more often than expected born of non-cohabiting women. No other maternal characteristic affected the risk in a significant way. There was no association found with maternal drug use.
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Epispadias, Cloacal and Bladder Exstrophy,Epispadias, cloacal and bladder exstrophy are related but rare malformations (n=99). Little effect of maternal characteristics was seen but overweight or obesity were associated with exstrophy but not with epispadias. Only few drug exposures were identified, none showed a significant risk increase.
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https://doi.org/10.1057/9781137000682defect registers around the world, started in order to detect a new thalidomide-like drug as quickly as possible. An international organization was formed in 1974, trying to coordinate data from the different registers and other international or national organizations exist.
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