Titlebook: Enzymology and Molecular Biology of Carbonyl Metabolism 5; Henry Weiner,Roger S. Holmes,Bendicht Wermuth Book 1995 The Editor(s) (if appli

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Zusammenfassende Diskussion der Ergebnisse,lastic drugs (Sladek, 1988; Lindahl, 1992). The cytotoxic effect is caused by alkylation reaction of these drugs with DNA and proteins inhibiting the cell proliferation. These chemotherapeutic agents are also extensively applied as immunosuppressants during bone marrow transplantation, and in autoim

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https://doi.org/10.1007/978-3-322-81341-1ic acids. The ALDH2 enzyme has a very low K. (<1 μM) for short aliphatic aldehydes such as acetaldehyde and propionaldehyde. In human beings, this isozyme appears to play a major role in the removal of acetaldehyde generated from the oxidation of ethanol. This conclusion is based on the study of ind

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Öko-Audit — eine genossenschaftliche Aufgabeived unless we are deprived of them, or they become deranged in some way”. Until recently, Harvey’s approach for elucidation of biological roles of a given enzyme (or protein) was feasible only in cases of rare genetic disorders. It has become possible to control the expression of a given protein vi

bromide

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https://doi.org/10.1057/9780230591387or polycyclic hydrocarbons such as 3-methylcholanthrene (3MC) and aromatic amines (Törrönen et al., 1981; Vasiliou et al, 1988; Marselos and Vasiliou, 1991). Induction of ALDH3c has also been observed in a number of extrahepatic rat tissues including lungs, spleen, urinary bladder, heart, and brain

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The Evolution of Human Longevity,Koshland (1964). In the work reported here, we have used 3, 4-dihydro-3-methyl-6-nitro-2.-1,3-benzoxazin-2-one (DMNB) to provide a reporter group for examining the nature of the active site in cytosolic aldehyde dehydrogenase from sheep liver.

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https://doi.org/10.1007/978-94-011-0151-6been shown to be a class 3 aldehyde dehydrogenase which is 84% identical to rat tumor-associated AlDH at the amino acid level (Cooper ., 1991). Abedinia . (1990) purified the bovine corneal AlDH and demonstrated that it was the major soluble protein in bovine cornea, representing 20 to 40% of the soluble protein.

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restrain

Lorraine Sherr,Fabrizio StaraceNitrate esters are used clinically as the smooth muscle relaxants (Needleman, 1975) in the treatment of angina pectoris. Guanine cyclase-mediated relaxation of aortic strips is dependent on the conversion of nitrate esters to nitric oxide by tissue sulfhydryl groups (Needleman and Johnson, 1973).