Titlebook: Enzymology and Molecular Biology of Carbonyl Metabolism 5; Henry Weiner,Roger S. Holmes,Bendicht Wermuth Book 1995 The Editor(s) (if appli

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The Evolution of Human Longevity,Koshland (1964). In the work reported here, we have used 3, 4-dihydro-3-methyl-6-nitro-2.-1,3-benzoxazin-2-one (DMNB) to provide a reporter group for examining the nature of the active site in cytosolic aldehyde dehydrogenase from sheep liver.

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https://doi.org/10.1007/978-3-642-85511-5ides of carboxylic acids could be reduced to aldehydes by enzyme.NADH mixtures. In a later study Motion . (1988) demonstrated that acylation of aldehyde dehydrogenase.NADH complexes by acetic anhydride led to the production of acetaldehyde and NAD. in stoichiometric amounts. It is clear from these r

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https://doi.org/10.1057/9780230379374der to extend these studies using site-directed mutagenesis it was necessary first to isolate and sequence the cDNA for this form of the enzyme. The cDNA sequences for the human liver cytosolic (Hsu ., 1989) and mitochondrial iso-forms of AIDH (Hsu ., 1988) were used to design a probe which would al

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https://doi.org/10.1007/978-3-319-48306-1karyotes. In animals, aldehyde dehydrogenases are found in a number of different bodily locations where they exist as several distinct isozymes. These enzymes share the general role of detoxification of aldehydes (Jakoby and Ziegler, 1990) but the individual isozymes show differences in specificity

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https://doi.org/10.1007/978-94-011-0151-6been shown to be a class 3 aldehyde dehydrogenase which is 84% identical to rat tumor-associated AlDH at the amino acid level (Cooper ., 1991). Abedinia . (1990) purified the bovine corneal AlDH and demonstrated that it was the major soluble protein in bovine cornea, representing 20 to 40% of the so

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https://doi.org/10.1007/978-3-642-73460-1uced during this process, malondialdehyde and 4-hydroxy.2,3-. nonenal (4-HNE) are the most abundant aldehydic products produced during lipid peroxidation. These two products of lipid peroxidation are,-unsaturated aldehydes and, as a result, are relatively strong electrophiles which are thought to be

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