Titlebook: Enzymology and Molecular Biology of Carbonyl Metabolism 3; Henry Weiner,Bendicht Wermuth,David W. Crabb Book 1991 The Editor(s) (if applic

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Charles R. Filburn,Edward G. Lakattatalyzed oxidation reaction at pH 7.0 and 7.6 is generally agreed to occur by the following ordered mechanism:.Scheme IAt least at low propionaldehyde concentrations, the rate of the reaction is controlled by the slow conformational change which occurs during the release of NADH from the enzyme (Blackwell et al., 1987; Dickinson, 1985).

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Biochemical, Immunological, and Molecular Characterization of a “High KM” Aldehyde Dehydrogenaseammalian liver ALDHs differ in their electrophoretic mobility, isoelectric point, molecular size, kinetic properties, inhibition with disulfiram, subunit structure, as well as in their cellular and tissue distribution, and chromosomal assignment.

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A Polymorphism in the Rat Liver Mitochondrial , Gene is Associated with Alcohol Drinking Behaviorich deters alcohol-drinking and thus reduces the risk of becoming an alcoholic. Japanese alcoholics have a low incidence of the ALDH2-deficient phenotype (2.3%) compared with the general Japanese population (41%) suggesting that polymorphism of . could play a role in an individual’s susceptibility to alcoholism (Harada et al., 1982).

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Aldehydic Products of Lipid Peroxidation: Substrates or Inhibitors of Hepatic Aldehyde Dehydrogenaseey are present in the greatest quantities during peroxidation of cellular membrane lipids while .-2-hexenal, acrolein and crotonaldehdye are representative of minor products of lipid peroxidation thought to be formed in significantly smaller quantities.

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Sleep, Biological Rhythms and Aging,ormed with either amino acid; a thiohemiacetal in the former, a hemiacetal in the latter. The intermediate would then be oxidized in the presence of NAD to produce a thioacyl or an acyl intermediate respectively, as illustrated in Fig. 1.

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Michael W. Rich MD,William J. Nienaber MDAlthough the latter two have important roles in health and disease, for the enzymologist HDH offers the advantage of a long and interesting genetic history, and is particularly well suited to molecular approaches.