Titlebook: Enzyme Cascade Design and Modelling; Selin Kara,Florian Rudroff Book 2021 Springer Nature Switzerland AG 2021 metabolic engineering.indust

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https://doi.org/10.1007/978-94-009-6735-9h technical benchmarks for volumetric productivities—especially for hydrophobic compounds—medium engineering, i.e. the choice of alternative reaction media opens new possibilities. Also, efficient downstream processing can strongly benefit therefrom. The upcoming advances in enzymatic cascade reacti

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Enzyme Cascade Design: Retrosynthesis Approach, include biocatalysis in recent years. The increasing number of transformations known to be catalysed by enzymes, whilst ultimately rendering biocatalytic retrosynthesis more powerful, necessitates the use of computational tools if biocatalysis is to reach its full potential. In the following chapte

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Design and Development of Chemoenzymatic Cascades,ey issue for developing such processes is to gain initially insight into the compatibility of the reaction steps being considered to be combined. It is noteworthy that for many chemoenzymatic reactions with an initial chemocatalytic step and a subsequent biotransformation, a high compatibility of th

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Enzyme Cascade Reaction Engineering,n order to build on these advantages, to reinforce them, and not to weaken them, as well as to ensure the fulfillment of economic framework conditions, it is important to harmonize the reaction with its best suitable reactor and operation mode. In this chapter, three ideal reactor types and their bi

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Enzyme Cascade Process Design and Modelling,enabling the synthesis of complex molecules of interest. When coupled with ex vivo cofactor regeneration, cascades provide the possibility for a potentially scalable synthesis. However, challenges of cross-reactivity and optimization as well as control suggest that modularization, rather than one-po

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Enzyme Cascade Reaction Monitoring and Control,ficient cascade reaction it is necessary to monitor these components, which enables an optimization of the overall system. The scope of this chapter is to provide knowledge about the basic principles of inline analytical technologies. Different definitions about the position and the type of measurem