Titlebook: Engineered Zinc Finger Proteins; Methods and Protocol Joel P. Mackay,David J. Segal Book 2010 Springer Science + Business Media, LLC 2010 A

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https://doi.org/10.1007/978-1-4302-0642-2ts are able to relax this structure, facilitating the access of transcription factors into the DNA. Herein, we describe a new method, which combines artificial transcription factors (ATFs) and chromatin-remodeling agents to specifically reactivate silenced regions of the genome and reprogram cellula

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https://doi.org/10.1007/978-3-030-31953-3enome engineering arena, including the therapeutic correction of mutated genes in the human genome. Gene editing frequencies of up to 50% in human cells under non-selective conditions reveal the power of the ZFN technology. Activity and toxicity of ZFNs are determined by a number of parameters, incl

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Leitlinien zur Verwundetenversorgunge endogenous target. Here we describe a simple procedure for quantifying mutations that result from DNA double-strand break repair via non-homologous end joining. The assay is based on the ability of the Surveyor nuclease to selectively cleave distorted duplex DNA formed via cross-annealing of mutat

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Leitlinien zur Verwundetenversorgungility of such methods would be of great value for basic mitochondrial research and would aid in development of therapies for diseases linked with mutations in mtDNA. Engineered zinc finger proteins have been used as powerful tools for intervening in nuclear gene expression and modifying nuclear DNA

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