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Titlebook: Endothelial Signaling in Development and Disease; Mirko HH Schmidt,Stefan Liebner Book 2015 Springer Science+Business Media New York 2015

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Development and Differentiation of the Lymphatic Vascular System dietary fats. This importance is highlighted by the contribution of the lymphatic vasculature to several human diseases, including lymphedema, tumor metastasis, and inflammation. In this chapter, we seek to review basic principles of lymphatic vessel biology and discuss the current understanding of
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Cytochrome P450-Derived Lipid Mediators and Vascular Responsesc acid, and docosahexenoic acid to generate bioactive lipid epoxide mediators. The epoxides thus generated demonstrate potent antihypertensive, angiogenic and anti-inflammatory properties. Endogenous epoxide levels are largely regulated by the soluble epoxide hydrolase (sEH), and the inhibition or g
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Axon Guidance Factors in Developmental and Pathological Angiogenesisthe vascular system, recent research shows that the sophisticated and multistep processes of vascular growth, guidance, and stability also require the participation of different molecular families that were first identified to have a role in the nervous system. This chapter will therefore focus on t
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The Angiopoietin—Tie System: Common Signaling Pathways for Angiogenesis, Cancer, and Inflammationaddition to their established functions during developmental and pathological angiogenesis, angiopoietins also provide a link between angiogenesis and inflammation. In this chapter we describe classical vascular functions and discuss novel aspects with regard to immune cell recruitment, as well as r
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Oxygen Signaling in Physiological and Pathological Angiogenesisc respiration. However, as a downside, the development of this obligatory alliance leads to risk-entailed side effects through the generation of reactive oxygen species (ROS). ROS can cause far-reaching damage to DNA and proteins. In order to avert serious harm, as well as to guarantee adequate oxyg
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