Titlebook: Endosomes; Ivan Dikic Book 2006 Springer-Verlag New York 2006 Lipid.membrane.protein.proteins.receptor.replication.signal transduction

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1431-0414 arious cargoes, mainly proteins and lipids, to distant cellular destinations. How endosomes function, what co-ordinates the molecular determinants at each step of their dynamic life cycle and what their biological and medical relevance is, are among the questions addressed in this book..978-1-4419-2292-2978-0-387-39951-5Series ISSN 1431-0414

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Lipid Membrane Domains in Endosomes,d that such territories overlap with morphologically visible domains. Here, we will discuss recent advances in our understanding of the role of these specialized membrane domains and protein-lipid assemblies in the endocytic pathway leading to lysosomes.

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Protein Sorting in Endosomes,es able to distinguish between cargoes. In this review we will highlight recent studies that are beginning to elucidate the endosomal sorting machineries that recognize different cargoes, as well as individual sorting signals that specify their destinations.

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Signaling from Internalized Receptors,he formation of specialized signaling platforms on intracellular vesicles. Thus, the investigation of the molecular composition of the various vesicular compartments, their interplay and their spatial and temporal regulation is crucial in order to fully understand the modality of cell signaling.

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Endocytic Trafficking and Human Diseases,n the secretory and endocytic pathways. This chapter highlights the molecular basis for selected diseases associated with defects in intracellular trafficking with a specific focus on disorders resulting from aberrant endosomal sorting.

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,Endosomes—Key Components in Viral Entry and Replication,mbly, or play roles in modulating anti-viral immune responses. To these ends viruses exploit various attributes of endosomes such as the low luminal pH, unique trafficking properties, cellular location and composition. In turn, viruses have become remarkable tools for analysing endosome function.

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Wo finden Schmerzpatienten Hilfe?,ther factors such as SM-proteins are also involved. In this chapter, we discuss fusion reactions of the endocytotic pathway, with particular emphasis on homotypic fusion between mammalian early and late endosomes, and between yeast vacuoles, with a main emphasis on the molecular mechanism of SNARE proteins.

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Wo finden Schmerzpatienten Hilfe?,e selective sorting in this pathway. Evidence suggests that the clathrin coat utilizes a diverse collection of clathrin-associated sorting proteins (CLASPs) to ensure the efficient and noncompetitive concentration of a wide variety of sorting signals within transport vesicles forming at the cell surface.