| 书目名称 | Emerging Targets in Antibacterial and Antifungal Chemotherapy | | 编辑 | Joyce A. Sutcliffe,Nafsika H. Georgopapadakou | | 视频video | | | 图书封面 |  | | 描述 | Emerging Targets in Antibacterial and Antifungal Chemotherapyoffers constructive ideas to researchers that could lead to thediscovery ofentirely new classes of drugs. The authors emphasize newtopicsrather than review work on known antibacterials andantifungals, andidentify new targets--either the rate-limitingcomponent of abiochemical pathway or a component of the pathway thatis susceptibleto a ``screening‘‘ or ``rational drug design‘‘approach. Each chapterreviews the biochemical pathway and its placein the cellular schemein order to place the target in perspective.The authors, a mixtureof academic researchers and drug-discoveryinvestigators inpharmaceutical companies, also extend thesetheoretical concerns intopractical applications and suggest usefulscreening methodologies.The importance of this subject area isdemonstrated by the increasingnumber of papers in the literaturethat point to potential targetsand screening methodologies for newantibacterials. This book alsodeals with antifungals, investigatingthe inherent limitations inexisting antifungals (many of which areextremely toxic or have onlylimited efficacy), and pointing to majordevelopments in thediscovery of novel antifung | | 出版日期 | Book 1992 | | 关键词 | DNA; Lipid; RNA; enzymes; lead; proteins | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4615-3274-3 | | isbn_softcover | 978-1-4613-6440-5 | | isbn_ebook | 978-1-4615-3274-3 | | copyright | Routledge, Chapman & Hall, Inc. 1992 |
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发表于 2025-3-21 16:18:37
