| 书目名称 | Emergence of In Vitro 3D Systems to Model Human Malaria |
| 编辑 | Kasem Kulkeaw |
| 视频video | |
| 概述 | Explores the applications of liver organoids for modeling human diseases.Illustrates the potential applications of in vitro 3D models for malaria research.Presents in-depth protocols and methods for l |
| 图书封面 |  |
| 描述 | .This book illustrates the importance and advances of the disease model for malaria, a globally affected public health problem. This book provides comprehensive information on the malaria biology in a liver and all in vitro platforms for liver-stage malaria, including principles, protocols, applications for disease modeling and drug screening, and their limitations. The initial chapter describes the basis of stem cells in liver generation during development and in adults. The subsequent chapters highlight recent and emerging advances in liver organoid and liver-on-a-chip in modeling malaria. The book presents current protocols and methods to generate liver organoid and liver-on-a-chip together with their advantages and limitations. Toward the end, the book examines the humanized mouse model of liver-stage malaria using ectopic artificial livers regarding novel readout modalities. The recent advancement and challenges in combining liver-on-a-chip technology with biosensors are highlighted for assessing hepatocyte development viability and functions. The book elucidates the potential of these 3D models to understand the biological complexity of cellular and molecular mechanisms invol |
| 出版日期 | Book 2023 |
| 关键词 | Malaria; Plasmodium; Liver stage; Liver Organoids; Liver-On-Chip |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-981-99-0691-8 |
| isbn_softcover | 978-981-99-0693-2 |
| isbn_ebook | 978-981-99-0691-8 |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapor |
发表于 2025-3-21 19:44:11
