Titlebook: Emergence of In Vitro 3D Systems to Model Human Malaria; Kasem Kulkeaw Book 2023 The Editor(s) (if applicable) and The Author(s), under ex

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Modeling and Simulation for RF System Designoids from pluripotent stem cells are the main focus here (Fig. 4.1). The current protocols to generate liver organoid together with tools for evaluating liver functions are provided. At the end of the chapter, a way to apply liver organoid for modeling liver-stage malaria is discussed.

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Introduction to Malaria Biology in a Liver,iver-stage malaria is reviewed, including the mechanism underlying the parasite entry into a hepatocyte, parasitic vacuole formation, proliferation, and hypnozoite formation. Following the basis of malaria, the actions of current antimalarial drugs targeting liver-stage malaria are explained.

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laria research.Presents in-depth protocols and methods for l.This book illustrates the importance and advances of the disease model for malaria, a globally affected public health problem. This book provides comprehensive information on the malaria biology in a liver and all in vitro platforms for li

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Generation of Liver Organoid,imited availability and uncertain quality. Importantly, pluripotent stem cells are capable of proliferating and differentiating into hepatic lineages, allowing the prescreening of specific phenotypes and the scaling up for high-throughput assays. Therefore, advances in generating liver/hepatic organ

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Design of a Liver-on-a-Chip,in and out. In a chip, single or multiple cell types attach on a very small area, while the fluidic flow passes the cells via a tiny channel. Given the fluidic flow, the organ-on-a-chip allows the cells to have a dynamic interaction with external stimuli (e.g., adjacent or distal cells and a gradien