Titlebook: Eicosanoids and the Gastrointestinal Tract; Keith Hillier (Senior Lecturer) Book 1988 MTP Press Limited 1988 gastrointestinal tract

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Alkaline secretion by the stomach and intestine: Effects of eicosanoids and anti-inflammatory drugstutes, along with the mucus layer, a first line of defence against acid in the stomach, and it is probably a principal protective mechanism in the duodenum.. In addition, bicarbonate secretion by the duodenal mucosa is considerably greater (per unit surface area) than in the stomach..

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Clinical uses of prostaglandins in peptic ulcer disease,he major aggressive factor, i.e. gastric acid—pepsin secretion. The progress in this direction has been highlighted by the discoveries of powerful inhibitors of the parietal cell receptors such as H2-receptor antagonists (Cimetidine and ranitidine), muscarinic receptor (Ml and M2) inhibitors (pirenz

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Protection against mucosal damage: Mechanism of action of eicosanoids,by which prostaglandins, given at non-antisecretory doses, prevent gastric and intestinal mucosal necrosis produced by a variety of noxious agents. This property was first demonstrated in experimental animals and has been reproduced in humans. Gastric cytoprotection can be divided into three types:

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