Titlebook: Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5; Kenneth V. Honn,Lawrence J. Marnett,Charles Serha

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Group IV Cytosolic Phospholipase A2(Pla2) Function:Insights from the Knockout Mouse,ds. This activity liberates free fatty acid and lysophospholipid. In eukaryotic cells the.position of membrane phospholipids is enriched with arachidonic acid and therefore the PLA.s are considered to be the first step in the regulated production of the eicosanoids. While eicosanoid production is of

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ineluctable

Participation of Cytosolic Phospholipase A2 in Eicosanoid Generation by Mouse Bone Marrow-Derived Mfirst step in the generation of these eicosanoids, is the liberation of esterified arachidonic acid from the sn-2 position of cell membrane glycerophospholipids by the action of phospholipase A2 (PLA2).. The family of mammalian PLA.enzymes includes the 85-kDa group IV cytosolic PLA.(cPLA.); at least

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Analysis of Cyclooxygenase-Substrate Interactions Using Stereospecificallylabeled Arachidonic Acids(Smith et al., 1996). The initial abstraction of the pro-S hydrogen at carbon C-13 is followed by oxygenation in the 11R position, formation of the endoperoxide and the five-membered prostaglandin ring, and, finally, a second oxygenation at C-15 to yield prostaglandin H2 (Hamberg and Samuelsson, 196

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Regulation Of Leukotriene C4 Synthase Gene Expression By Sp1 And Sp3 In Mononuclear Phagocytes,nthase (M. of 16,568; EC#2.5.1.37) is a selective, membrane-bound glutathione-S-transferase that catalyzes the conversion of LTA4 to LTC4. Although LTC4 synthase enzymatic activity is found in various cell types, mRNA for LTC4 synthase is present only in eosinophils, basophils, mast cells, and cells

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Pgg211r-Hpete and 15r/S-Hpete are Formed From Different Conformers of Arachidonic Acid in the Prostne A2 (.-.). PGHSs catalyze two separate reactions: a cyclooxygenase reaction in which arachidonate is converted to prostaglandin G2 (PGG.) and a peroxidase reaction in which PGG.undergoes a two-electron reduction to PGH.. The cyclooxygenase reaction begins with a rate-limiting abstraction of the 13

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fringe

Inhibition of 5-lo Activating Protein (Flap) Activity Decreases Proteinuria in Streptozotocin(Stz)-ributing factor to the tubulo-interstitial injury which underlies and often predicts progressive renal insufficiency in patients with primary glomerular diseases. Increasing recognition of the mechanisms whereby proteinuria leads to tubule injury confirms the well-known clinical observation that the

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Cyclooxygenase-2 Expression and Activity are Induced by Amyloid-Beta 1-42 in Brain-Derived Cells,duct of the transmembrane glycoprotein, amyloid precursor protein. Excess A13 within the brain has long been thought to play a major role in AD pathogenesis, however, the mechanisms of its actions are highly debatable. Recent evidence suggests that inflammation may be the pathogenetic link between A